Epigenetics and Aging

What epigenetics is, what aging clocks measure, and where the evidence is strong vs hype.

Intro

Epigenetics is often presented as the bridge between genes and environment. This guide will separate what is well-established from what is marketing.

Key Points

  • Epigenetics regulates gene expression without changing DNA sequence
  • “Aging clocks” are biomarkers, not destiny
  • Short-term clock changes don’t automatically mean long-term benefit

FAQ

Q: What is epigenetics?
A: Regulation of gene expression via chemical modifications (e.g., methylation) without changing DNA sequence.

Q: What do epigenetic clocks measure?
A: DNA methylation patterns correlated with age and risk — informative, but not perfect.

Q: Can you reverse epigenetic age?
A: Clock shifts are possible; outcome significance remains uncertain.