Lipoprotein(a): The Overlooked Genetic Heart Risk Factor

What Lp(a) is, why it matters, and who should get tested.

Intro

Lipoprotein(a), or Lp(a), is a genetically determined risk factor for cardiovascular disease.

It is not included in standard cholesterol tests.


Key Points

  • Lp(a) is inherited and largely fixed
  • High levels increase risk of heart attack and stroke
  • Often missed in routine testing
  • Recommended at least once in a lifetime

🚨 Breakout: The Blind Spot

You can have normal cholesterol and still have high Lp(a).

Standard tests won’t detect it.


Mechanism

Lp(a) promotes:

  • Atherosclerosis
  • Inflammation
  • Thrombosis

Who Should Test

  • Family history of early heart disease
  • Unexplained cardiovascular events
  • Borderline risk

FAQ

Q: Can Lp(a) be lowered?
A: Limited options currently, though new therapies are emerging.

Q: Is one test enough?
A: Usually yes—levels are genetically determined.


Further Reading